Chloroquine Coronavirus treatment in india – ICMR suggest Chloroquine Coronavirus treatment in India

Chloroquine Coronavirus treatment in india – ICMR suggest Chloroquine Coronavirus treatment in India


Good Evening Friends, Welcome back. Again your friend Dr.
Deepak Chaturvedi talking about Corona COVID1. So after a lot of
scare and other things, let’s talk some some optimism and with the current
News coming up “chloroquine” or “hydroxychloroquine” being, bringing some hope to the corona Covid19 patients Let’s talk about Chloroquine in a
nutshell. So what is chloroquine ? Chloroquine is a widely available
anti-malarial drug which is used both for the prophylaxis of malaria as well
as the treatment of malaria, other than malaria Chloroquine or hydroxychloroquine has
already, is already approved for the treatment of some sort of autoimmune disorders like
Rheumatoid Artyhritis, SLE even in diabetes chloroquine plays some role, lepra reaction, the reaction the immunological response of the body against the treatment of leprosy that is
actually curtailed by or taken care by the chloroquine. Other than Malaria
is also used against Hepatic or Liver Amoebiasis against Entamoeba Histolytica
other infections Giardia lamblia where chloroquine is used it has some other
properties like we know it can work like a muscle relaxant, it is a Local irritant, it can work like a local anesthetic and even definitely in the injectable. it has got some anti-arrythmic properties
also it is both pro-arrythmic as well as anti-arrythmic and above all it has got anti-inflammatory property and this probably is going to help a lot when we
talk about management of Corona Covid19 nineteen
infection. Now when we talk about corona COVID19 infection and the
potential role of chloroquine in that, lets understand how probably chloroquine
may help in the curtailing the corona CoVid19 infection complications as
simple as that? So, for a virus for corona Covid19 Virus to integrate in
your in your cells what is required ? what is a particular pH?
pH means acidity or alkalinity of your body fluids It is required for the
reaction to happen. Then some sort of receptor on the cell which, is being
talked a lot about in last few days ACE2 receptor (angiotensin converting
enzyme 2) receptors and again whenever we talk about ace2 receptor again one more theory comes out is whether to you ACE inhibitor in current world or whether ACE
inhibitors are going to increase the chances of complications of CORONA is again a matter of debate and discussion which we will talk in the next video or the
coming videos. But for understanding a particular pH is required. This
integration of the virus to the ACE2 receptor on the cell surface is required
with which the virus will find the PASSAGE inside and
then there is for the replication of the virus inside the CELL you
need something called as “RNA dependent RNA polymerase ” technical term “YES” there is no simple term for it so RNA dependent RNA polymerase is one of the enzyme which is required for the replication of this virus inside the cell. So anything which
is going to affect all these three things definitely going to have some
role in curtailing the the replication of the virus inside the body and then
converting from conversion of infection to the disease or complication and here
is where Choroquine can play some ROLE so what is Chloroquine Doing? So Chloroquine is altering the pH of the cell which is actually required and
which is actually a particular pH is required by the virus to get integrated.
Now that pH is altered so that’s how it is chloroquine is inhibiting that one step.
Second is Chloroquine is supposed to break this ACE2 receptor and the Virus linkage. How ? Again studies will come and
tell how it is happening but it is hampering this linkage and third very
important is chloroquine indirectly is inhibiting the RNA dependent RNA
polymerase so it is blocking the or it is inhibiting the replication of the
virus. Now that is the most interesting part the third one so how this group is
inhibiting the RNA dependent RNA polymerase? So the hypothesis is Chloroquine is ZINC INOPHORE. What do you mean by Zinc INOPHORE? So ZINC is too much there in
our body zinc is enough ample amount in our body but it is having some charge on
itself, two positive charges so it is not too much inside the cell it is more
Extracellularly n the body and then there are some active transports which
take the zinc inside the cell which is concentration dependent and what not but , what INOPHORES or zinc INOPHORES do ? They facilitate the passage of zinc from
the extracellular space inside the cell and chloroquine is one of the ZINC Inophore and this zinc when goes inside the cell this is the one which actually
inhibit this RNA dependent RNA polymerase and that’s how the
replication is inhibited or restricted the replication of the viral RNA and so
that’s how Chloroquine is through the through the part or through the passage or I should say through the pathway of being Zinc Inophore increases the
intracellular zinc which then inhibit the RNA RNA polymerase and that’s how the replication is inhibited or decreased or blunted . So three ways First pH Second ACE2 receptor and VIRUS integration and the third is by inhibiting the RNA dependent
RNA polymerase is through the same pathway and this Intracellular Zinc when it goes
inside, it also does one job that is it calls the vitamin D also inside and
vitamin D we all know works on innate immunity so one is Chloroquine is working as a ZINC INOPHORE so bringing the ZINC inside which is then
RESTRICTING the RNA dependent RNA polymerase but along with that vitamin D
is also coming in and which is improving the innate immunity and that’s how Chloroquine is working in Corona COVID19. “CAN WORK” in Corona Covid19 infection and a lot of things have been proven. chloroquine was being used even for SARS before , so if it
can work in SARS it should work in the CORONA COVID19 and also this hypothesis of
intracellular ZINC it works from other viruses also like HEPATITIS E and all. And enough studies are there, So we have enough supporting data indirect data
right now which say that Chloroquine or hydroxychloroquine can be used in
curtailing the CORONA COVID19, disease of Corona Covid19, extent of
infection in a particular individual and after all of that Chloroquine itself is Anti inflammatory. So being an inflammatory it checks the neurological response of
the body to go robust and to go self-destructive and that’s how
chloroquine is also curtailing the symptoms of Coronado v19 infection. So at one site blocking the replication on the other side not giving access to the
virus to enter in the cell and on the third side maintaining the immunological response of the body to not go in the self destructive mode.
chloroquine can be a potential management tool to control the extent of
the complications in any CORONA COVID19 infection and then lot of other
things have come now. Lot of guidelines are coming from various institutions
AIIMS has come with there guidelines, South Korea with there Guideline, China with there guideline and
chloroquine with Azithromycin has found a place in all the
guidelines which we will talk in our further videos, But the only the question
which is coming is. Can chloroquine prevent the infection ? and that is, I
think I personally feel if we promote like that way that Chloroquine will be preventing the infection it is going to go – in a negative side
I mean everybody will be now running behind chloroquine in a I like the way people ran behind masks and another things and suddenly there will be a acute
shortage of Chloroquine in the market and people will be just popping up Chloroquine and getting the side effects of it “nothing is SIDEEFFECT free” and the people who really need them will be devoid of getting the Chloroquine or hydroxychloroquine. Black marketing will start happening so lets not promote it as a preventive tool that you just pop up and you are done , NO lets not promote it that way but yes because we don’t have much right now to prevent
the disease to happen from infection to disease. we don’t have much
for that their Chloroquine can work and let’s keep it for them so it should not
happen that we are popping this pill and letting somebody die of the CORONA COVID19 complications. With that I would like to make this as a as a request to
all the health authorities to make it very very clear , so people don’t HOARD
chloroquine or HYDROXYCHLOROQUINE in their homes just because they feel
that it can can save them from even getting the infection .To protect the
infection the only proven thing at this point of time, I will again come back to
that point again and again is “BLOCK THE TRANSMISSION” chain so you maintain your HYGIENE and along with that social distancing for the masses ,Quarantine for the
contacts and ISOLATION for the cases and all the cases you manage with Chloroquine and with all the other modalities what we already have. So with
this I would like to conclude this video I hope this video will help you in a
certain way and will clear some of your confusion which are coming in your mind
and if you have any more confusion feel free to contact your doctor you health
care provider authorities or even me I will more than happy to answer you thank
you so very much